ArachnoServer is a manually curated database containing information on the sequence, three-dimensional structure, and biological activity of protein toxins derived from spider venom. Spiders are the largest group of venomous animals and they are predicted to contain by far the largest number of pharmacologically active peptide toxins (Escoubas et al., 2006). ArachnoServer has been custom-built so that a wide range of biological scientists, including neuroscientists, pharmacologists, and toxinologists, can readily access key data relevant to their discipline without being overwhelmed by extraneous information.

All spider toxin entries are sourced from UniProtKB/Swiss-Prot then manually curated by our expert team using available literature and patent information. Spider taxonomy is based on the latest version of the authoritative World Spider Catalog. A key feature of ArachnoServer is the use of a molecular target ontology based on the channel and receptor subtype definitions recommended by IUPHAR. Moreover, in addition to any legacy synonyms, all peptide toxins in the database have been assigned names according to the recently described rational nomenclature for spider toxins (King et al., 2008).

ArachnoServer allows advanced searches of toxin information, browsing, as well as similarity searches using BLAST. Each toxin record is displayed in a single page and, where available, a toxin's structure can be dynamically visualised.

You can get started by using the search box at the top of each page to search toxin names, synonyms, spider common names, and spider taxonomy. For advanced searches, click either the 'search' tab or the 'advanced' link below the search box. Help snippets are available at the top right corner of the 'search', 'browse' and 'blast' pages. You can download the user manual using the link at the top of each page.

Please find an example of curated toxin card here

Database Information

Toxins (total) 1576
Toxins (curated) 1458
Species 100

Please visit the download page to
download data from ArachnoServer.

UPDATE: Please try out Tox|Note, our new pipeline to significantly fast track the analysis of spider venom-gland transcriptomes, by isolating all toxin/ toxin-like sequences generated by large Next Generation (NG) sequencing projects.

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If you used ArachnoServer for your research and found it useful, please cite the manuscript:

Sandy S Pineda, Pierre-Alain Chaumeil, Anne Kunert, Quentin Kaas, Mike W C Thang, Lien Le, Michael Nuhn, Volker Herzig, Natalie J Saez, Ben Cristofori-Armstrong, Raveendra Anangi, Sebastian Senff, Dominique Gorse, Glenn F King; ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins Bioinformatics, Volume 34, Issue 6, 15 March 2018, Pages 1074-1076,