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| Toxin Name |
U1-theraphotoxin-Lsp1a |
| Source Species |
Lasiodora sp. |
| Toxin Group |
Theraphotoxin |
| Description |
A toxin with unknown molecular target and activity. The spider is a Lasiodora species from the state of Minas Gerais in Brazil. It is clearly closely related to Lasiodora parahybana, which contains a toxin (U1-TRTX-Lp1a) whose primary structure is identical to the mature toxin region of U1-TRTX-Lsp1a. |
| Discovered |
2004 |
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| This toxin last updated on Dec 20, 2009 |
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| Current Taxonomy |
| Kingdom |
Animalia |
| Phylum |
Arthropoda |
| Class |
Arachnida |
| Order |
Araneae |
| Infra-order |
Mygalomorphae |
| Family |
Theraphosidae |
| Genus |
Lasiodora |
| Species |
sp. |
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| Molecular Target |
ED50 |
IC50 |
Kd |
Pharmacophore |
Comment |
| Molecular target unknown |
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| Original Deposition References |
Vieira, A.L., Moura, M.B., Baba, E.H., Chavez-Olortegui, C., Kalapothakis, E. and Castro, I.M.
Toxicon 44:949-952 (2004)
Molecular cloning of toxins expressed by the venom gland of Lasiodora sp.
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| Disulfide Bonds |
| Left Residue |
Right Residue |
Evidence |
| 4 |
17 |
By homology |
| 8 |
41 |
By homology |
| 22 |
24 |
By homology |
| 35 |
46 |
By homology |
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| Peptide Sequences |
>as:U1-theraphotoxin-Lsp1a|sp:P0CC19 Toxin with unknown activity and target from the venom of the spider Lasiodora sp.
MRSLTLAALLLCSLLLVFHTSAAAELEAQEGHLMIPGDTDTALETVDDERFFECTFECDI
KKEGKPCKPKGCKCKDKDNKDHKKCSGGWRCKLKLCLKF |
Full BLAST |
BLAST mature toxin only
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| mRNA Sequences |
>as:U1-theraphotoxin-Lsp1a|gb:AY794219 cDNA sequence of a toxin from the venom gland of the spider Lasiodora sp.
GGCACCAGCTTCGTAGTATCTGAACTTCAGGAGAATTTCAAGCAAAAGATGAGATCTTTG
ACGTTGGCTGCTCTTCTGCTATGCAGCTTGCTGTTAGTTTTTCACACTTCAGCAGCTGCA
GAGCTTGAAGCTCAGGAAGGCCATCTGATGATCCCCGGTGATACTGACACCGCCCTAGAA
ACTGTCGATGATGAAAGATTTTTCGAATGTACTTTTGAATGCGACATTAAAAAAGAAGGC
AAACCATGCAAACCCAAGGGATGCAAGTGTAAGGACAAGGATAACAAGGATCACAAGAAA
TGTTCTGGTGGATGGAGATGTAAGCTCAAGCTCTGTTTGAAGTTTTAGTATGAAAACTGG
CCAGGTGCTGCCATCACTACGAGAAAACTCACCATAACATGCACACGAAGAGCTATTCTT
GGTGATGCTGTAGCAAATGTATTAACATGTTAGCCAGAAATGTTGTTTGAATTATATTAT
GTATCTGAAAAATCGTTAATAAAATAGTTTCAACCTTTCAAAAAAAAAAAA |
Full BLAST
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| Synonym |
Type |
| U1-theraphotoxin-Lsp1a |
Recommended full name |
| U1-TRTX-Lsp1a |
Recommended abbreviation |
| LTx1 |
Synonym |
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